The Rosa webbiana Wall ex.Royle belongs to the family Rosaceae that consist of about 200 species, which are distributed all the way through the temperate and sub-tropical habitats of the northern hemisphere. Most of the wild rose species are found in Asia. Two new and three known compounds were obtained from Rosa webbiana. The family is famous for ethno-medicinal uses, therefore, we elected Rosa webbiana Wall ex.Royle for the isolation of molecular-constituents to correlate the ethno-medicinal properties with the isolated constituents. During our conventional attempt for isolation two new compounds; (E)-1-(3-butyl-2, 4, 6-trimethylcyclohexyl)-5-phenylpent-2-ene-1, 4-diol (1) and N, N-bis (2-ethylhexyl)-2-(phenylthio) acetamide (2) and three known compounds; Isonicotinic acid, undecyl ester, 4-Butylbenzoic acid (3), 4-methoxy-2-methylbutyl ester (4) and Linoleamide (5) were purified and characterized using modern techniques the nuclear magnet resonance (NMR) spectroscopy. The new molecular-constituents (1 and 2) were tested against asthma using PatchDock server and it was found that the constituent (1) was more effective against asthma, thus it is confirmed that the plant may be used against asthma.
Chronic liver disease (CLD) refers to a structural and functional change of the liver, which modifies the pharmacokinetics of multiple drugs, including hypoglycemic agents. This alteration depends on the severity degree of the liver disease, clinical characteristics of the patient, and comorbidities presence such as kidney disease and drug biochemistry. Insulin is considered a safe therapeutic strategy in patients with CLD, however, for many oral hypoglycemic agents, its use and dose adjustment will depend on the Child-Pugh score, taking into account the high risk of hypoglycemia of this type of patients
ABSTRACTRomania has a high tourism potential, but the performances do not rise to the same level. Having in view the position of the Romanian tourism in the international competition, there is an urgent need for new strategies and specific policies for the rehabilitation of this branch, and this is one of the objectives of the present research. There were rehabilitation intentions in the years before, mainly after Romania�s accession to the EU, but the results were not those expected. From these reasons, we would like to analyze the main factors that have influenced the evolution of Romanian tourism, the strategies and policies elaborated in the past, which are the main directions in tourism development and what kind of programs the Government must promote to increase the competitiveness of this sector. We made a statistical analysis based on NIS and Eurostat official databases and a qualitative analysis of the main official documents elaborated by authorities in the field. The results will show us which are the determinants of the present competitiveness and which are the best strategies, policies and programs for the future.