Objective: Ischemia/reperfusion (I/R) injury is one of the most influential factors affecting graft survival. The aim in this study is to evaluate the preventive efficacy of the IL-18 Binding Protein (IL-18BP) in preventing ischemia/reperfusion injury in an autologous renal transplant model in rats.\nMethods: Group 1 (Sham): The abdomen will be opened and then closed again after a right nephrectomy. Group 2 (I/R): Following a right nephrectomy, the left kidney will be perfused with a 0.9% saline solution. Group 3 (I/R&UW;): Following a right nephrectomy, left kidney perfused with a University of Wisconsin (UW) solution. Group 4 (IL-18BP): IL-18BP (100µg/kg) will be administered intraperitoneally 30 minutes. The left kidney will be perfused with a UW solution. The left kidney will be removed after 24 hours for analysis. \nResults: When the serum and tissue cytokine levels were analyzed, IFN-γ, TNF-α, IL1-β, IL-6 and IL-18 levels were found to be significantly decreased in the sham group when compared to the levels in the I/R group. Serum and tissue TNF-α, IL1-β, IL-6 and IL-18 levels were found to be significantly decreased in the treatment group compared to the levels in the I/R group. TAS levels were increased in the treatment group, whereas TOS and OSI levels were significantly decreased in the IL-18BP treatment group, and a histopathological evaluation revealed tubular degeneration in the same group. \nConclusion: The IL-18BP has antioxidant and anti-inflammatory effect on renal I/R injury.

Abstract\n Proteomics is the study of platelet proteins with the molecules that regulates unknown platelet functions associated diseases related to the platelets. Various application of proteomics includes: to study (a) whole platelet proteome in either resting or activated condition (b) platelet subproteomes granules and micro-particles (c) platelet PTMs (phosphosproteome, glycoproteome, palmitoylome). LCMS analysis was performed in Thermo Orbitrap fusion tribird mass spectrometer coupled with an EASY-NLC 1200 series system after the protein pellets were dissolved in urea buffer (8M urea/2M thiourea) and then sample concentration were evaluated utilizing Nanodrop. 34 de-novo proteins were identified and analysis was done. Fold change >1.5 considered as down-regulation of the protein expression in comparison to control group while fold change <0.98 consider as down-regulation of protein expression. Platelet proteomics provides astounding information about underline platelet-related diseases, though several other changes still remain to be studied. However, we are confident that the in-cooperation of the most recent advances in MS-based techniques in platelets proteomics studies will allow further description of the mechanisms implicated in diseases and find out new biomarkers or drug targets.\n\nKeywords: Proteomics, Platelets ,Human, Platelet additive solution

The purpose of this study was to analyze the factors affecting capital structure in Indonesia. The variables used were DER as the dependent variable and as independent variables are profitability, growth opportunity, fixed asset tangibility, size, dividend payout ratio and short-term debt to total assets. The sample used in this study is a company registered in LQ-45. And selected by using purposive sampling. Thus obtained 38 companies as a sample. The analytical method used is linear regression. \nThe results obtained from this study is the variable profitability, tangibility fixed assets and short term debt to total assets that have a significant influence 5%. While the growth opportunity and size variables have a significant influence 10%. While the variable dividend payout ratio does not have a significant influence.

After careful review of Iran’s condition in constitutional period, in this paper we are trying to find the roots of failure of the democratic system after Iranian constitutional revolution. According to two fundamental issues of social and political structures in post-traditional discipline of Anthony Giddens, it can be realized that constitutional movement in Iran which is considered as a modern and democratic movement can be regarded as a rebel against the king not a social revolution occurred against the authoritarian structure. \\nDue to unfavorable cultural and intellectual fields in Gajar, constitutional revolution in Iran couldn’t cause deep changes and dominate on undemocratic structure. Therefore, even after the constitutional movement, the previous social structure has existed.

All technical systems have been designed to perform their intended tasks in a specific ambient. Some systems can perform their tasks in a variety of distinctive levels. A system that can have a finite number of performance rates is called a multi-state system. Generally multi-state system is consisted of components that they also can be multi-state. The performance rates of components constituting a system can also vary as a result of their deterioration or in consequence of variable environmental conditions. Component failures can lead to the degradation of the entire multi-state system performance. The performance rates of the components can range from perfect functioning up to complete failure. The quality of the system is completely determined by components. In this article, possible states for the components are considered under stress-strength model which makes the components multi-state. The probabilities of components are studied when strengths of the components are Erlang random variables and the stresses are independent exponential random variables. Also, the probabilities of components are considered when the stresses are dependent exponential random variables.

The European flat oyster, Ostrea edulis L, represents an important economically oysterproduction in Southern Italy, widespread in natural beds along the coast. The practice to beeaten raw is an everlasting concern for possible health risk, needing stringently to monitorthe health of aquatic environment. A screening survey, for hystopathological examination,was undertaken by harvesting O. edulis from different sites along the Apulian coast:Manfredonia, Margherita di Savoia, Monopoli, Taranto and Tricase. Tissue samples ofdigestive gland, kidney, gonad and gill were provided for morphologic study in LightMicroscopy (LM), Transmission Electron Microscopy (TEM) and Scanning ElectronMicroscopy (SEM) analysis. LM observations revealed spherical cytoplasmic inclusions,as basophilic prokaryote colonies in about 5% of oysters. TEM and SEM confirmed thepresence of intracytoplasmic inclusions of Rickettsia-like organisms (RLOs), merely in theepithelial cells of digestive gland tubule tissues of 13 adults. Within intracytoplasmicvacuoles, RLOs exhibited a prokaryotic characteristic ultrastructure with transverse binaryfission, a DNA zone full of chromatin fibers and a granular periplasmic ribosome zone. O.edulis were found positive for RLOs in wild oysters from Manfredonia, while the othersites were found free of pathological inclusions. We present the first report of a Rickettsialikeinfection in the Apulian wild oyster O. edulis from Italy, including an ultrastructuraldescription and pathological characterization.