The Australian spotted jellyfish Phyllorhiza punctata, was reported on November 28, 2018 in Port Said, the southeastern Mediterranean coast of Egypt. This is the second record from Egypt. The first record was in 1991 in Al-Arish coast. This species is native to the southwestern Pacific and was introduced to the western tropical Atlantic by the mid XX century. Phyllorhiza punctata first appeared in the Mediterranean off the Israeli coast in 1965. Since then, it has been reported at various coastal waters along the Mediterranean either as few specimens or recently as swarms, especially in the western basin.

Diabetic foot syndrome that affects patients under regular haemodialysis is a complex mechanism mainly based on patient metabolism, neurosensitive abnormalities, and plantar pressure dysfunctions. \n In this work, we study the clinical and biological profile of the diabetic foot in 43 Tunisian diabetic patients under regular haemodialysis.\n The majority of the patients have type 2 diabetes. All had diabetic nephropathy and several comorbidities, 57% secondary hyperparathyroidism, 35% had a normalized proteins catabolic rate, and 44.1% had hypoalbuminemia. Fifty one percent of the patients have feet deformities; among them respectively 44.1%, 25.6% and 34.8% have toes claws, hallux valgus and a history of ulceration or amputation.\nThirteen patients had diabetic neuropathy and 53.48% had sensory neuropathy. Neuropathic pain was found in 18.6% of patients.\n Regarding factors related to haemodialysis, the impact of “nutritional, inflammatory, anemic and disorders of the metabolism of calcium and of phosphorus” factors was clear. Diabetes inherent factors such as, duration of evolution, balance, and the tendency to obesity represent others complicating risk factors for our patients. Also, Systolic Pressure Index, which constitutes another risk factor, was greatly increased. Similarly, sensory and autonomic neuropathies were strongly present, as well as bone deformities. All these different factors are well known for their primordial impact on foot ulcers development.

In this paper, we introduce the Hyperbolic Pell numbers and we present recurrence relations, Binet’s formula, genrating function and the summation formulas for these numbers. Morever, we investgate Lorentzian inner product for the Hyperbolic Pell vectors.

This paper proposes the application of the intelligent based Systems for effective design of mechanical engineering based systems and its optimization. Intelligent based methods have been considered as a promising technology for design next generation mechanical engineering based systems. Agent based systems; one of the techniques of the intelligent based methods differs from other conventional techniques for designing mechanical based systems. Various researches have done using the intelligent based systems for identifying the faults while designing the mechanical based systems. It is also used for optimizing the shape, size, architecture of mechanical based systems and the properties of material such as two and three dimensions and its coupled structures etc. as an implementation methodology. This paper provides a literature on the recent works done in these areas based on the fault diagnosis perspective, and discusses some key issues in implementing intelligent-based efficient mechanical fault identification system. This paper also proposes a novel model for identifying the mechanical fault using an optimization algorithm, classifiers selection based on the entropy based feature and an intelligent multi-agent based algorithm for classification.\nKeywords: Mechanical engineering, Fault Analysis, Optimization, Intelligent based methods.\n1 Introduction\nAn explosive growth in intelligent based systems has witnessed in the past decade. Artificial Neural Networks (ANN), agent based systems, optimization techniques are some of the examples of intelligent based systems. Intelligent based systems is applied recently across most the engineering applications such as computer-based applications, mathematics-based applications and mechanical engineering-based applications. It comes beneath the mostly programming system in an engineering application. Fault diagnosis process in mechanical engineering based devices is becoming much more complex as the number of components continues to increase. Due to this difficulty, it is necessary for computerized intelligent based methods for finding the defects in mechanical engineering based devices\nNowadays, the modern mechanical engineering systems were becoming more costly and complex because

The aim of this study is to investigate multidrug resistance-associated protein 1 (MRP1) gene expression levels and anticancer activity of siRNA and Etoposide loaded Poly-hydroxybutyrate (PHB) coated magnetic nanoparticles (MNPs) on MCF-7/S and MCF-7/1000Eto cells. For this purpose, PHB coated magnetic nanoparticles were prepared by coprecipitation of iron salts by ammonium hydroxide. The novel synthesized PHB-MNPs, which have targeting potential under a magnetic field, were characterized by Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM), and transmission electron microscopy (TEM) analyses. Etoposide was loaded onto the PHB-MNPs. The in vitro cytotoxicity analysis of siRNA and Etoposide-loaded PHB-MNPs was performed on cancer cells. The expression levels of MRP1 related to drug resistance were shown using quantitative real-time PCR (qRT-PCR). The IC50 values of Etoposide on MCF-7 and MCF-7/1000Eto cells were identified as 50,6 μM and 135,7 μM, respectively. IC50 values of siRNA and Etoposide loaded PHB coated magnetic nanoparticles were identified as 10,18 μM and 39,21 μM on MCF-7 and MCF-7/1000 Eto cells, respectively. According to the gene expression results, MRP1 expression was 4 fold upregulated in MCF-7/1000Eto cells. However, it was about 3 fold downregulated due to the application of siRNA-Etoposide loaded magnetic nanoparticles. The results of this study demonstrated that siRNA and Etoposide loaded PHB coated magnetic nanoparticles can be a potential targeted therapeutic agent to overcome drug resistance.

Aims: The aim of the study was to investigate the effect of pre-pregnancy body mass index on weight gain during pregnancy.\nMethods and Material: This retrospective study was conducted on family medicine units in Turkey between March 2018 to September 2018. Pregnant files of the last 5 years were scanned and a questionnaire with 40 questions was filled. \nResults: 1061 pregnants from 72 provinces included in the study. The mean body weight of the patients before pregnancy was 62 ± 11 kg (Min 44 - Max 111). The mean BMI (Body mass index) before pregnancy was 24.4 ± 4.3 (Min 16.2 - Max 41.6). The net weight difference at the end of the pregnancy was 12 ± 5 (Min -4 - Maximum 47). Net weight difference during pregnancy was significantly higher in cesarean patients, in civil servants and in those with first pregnancy compared to 4 and 5 pregnancies (p <0.05). Net weight difference was found to be significantly lower in those without education compared to other groups (p <0.05). \nConclusions: Consequently, BMI should be within normal limits before pregnancy was planned. Individual weight gain should be planned during pregnancy. Conditions that increase or decrease weight gain during pregnancy should be tried to be controlled or corrected. Thus, many complications that may develop in the mother and baby can be prevented. In this regard, benefiting from family medicine units that can reach all segments of the society and monitor pregnant women can increase their success rates.

This research is very topical due to the problem of processing fish by-products from the production of canned food “Sprats in oil”. The aim of the study was to justify the complex processing of smoked sprat heads using the method of high temperature thermal hydrolysis. The new technology was tested with fatty (24%) and medium fatty (13%) raw materials using high temperatures in the range of 130-160 °С. As a result, the hydrolyzed organic mass was separated into fat, protein, mineral-protein and protein-fat emulsion fractions. Freeze-drying of the protein fraction and convective drying of the protein-mineral fraction resulted in food additives containing, respectively, low molecular weight water-soluble peptides and high molecular weight insoluble proteins and minerals. A rational method of hydrolysis is substantiated, including preliminary separation of fat in fatty raw materials and its enzymatic-thermal treatment. The optimal values of temperature and duration of hydrolysis in reactor are substantiated. Under these conditions, proteins are extracted most deeply from sprat raw materials, and the content of low molecular weight peptides in the protein freeze-dried hydrolysate powder is more than 80%. A comprehensive technology has been developed for the production of protein, fat and protein-mineral food additives from sprat processing by-products. The balances of organic substances for the main operations were calculated. The additives have pleasant organoleptic characteristics, are sanitary safe, positively tested in some food samples. The developed method for processing of smoked fish by-products is economically viable It allows to produce valuable food products from secondary raw materials and solves the environmental problems of recycling of smoked fish by-products.