PT. XY became one of the companies in West Java by implementing an organic farming system. The company uses the concept of agricultural cultivation free from artificial chemical fertilizers and insecticides with permaculture and aquaponics systems. Aquaculture innovations applied to the company do not always produce sweet results directly, although the application of the concept has reduced costs but has not been able to obtain maximum business benefits. Competition in aquaponics marketing and competitiveness in similar fields have also become polemics in the world of aquaponics. In this research, the main focus is to find a business to customer (B2C) development model that is suitable for selling aquaponic products for PT. XY. The research method used is a case study, which is a qualitative approach. Data is processed and analyzed descriptively and using SOAR tools (Strenght, Opportunities, Aspiration, Result) and analysis matrices. The results of this study show that: (1) marketing strategies that can be applied at PT XY based on SOAR analysis (strength, opportunities, aspirations, results) are Market Penetration and product development strategies; (2) The right B2C development model for PT. XY is a Business Model Canvas, which not only pays attention to nine elements, namely 1) Customer Segment, 2) Value Propositions, 3) Channels, 4) Customer Relationship, 5) Revenue Streams, 6) Key Activities, 7) Key Resources, 8) Key Partners, and 9) Cost Structure but also XY Company must pay attention to three other elements, namely: 1) Revenue Stream, 2) Eco Social Cost, and 3) Eco Social Benefit because the product of sale is aquaponic vegetables.

Green packaging can be a solution to the problem of environmental pollution caused by the generation of plastic waste as a result of bakery business packaging. However, bakery businesses still don\'t use green packaging a lot, which indicates low interest in using green packaging. This study aims to determine the most important factors underlying consumer interest in the use of green packaging. For that used factor analysis. The research was conducted in Indramayu Regency , West Java, Indonesia, from February to May 2023. The results showed that consumers\' interest in using green packaging was in the high category. The most important factors based on consumer ratings are hygiene, environmental benefits, and affordability.\nKeywords: Interest, Consumer, Bakeries Business and Green Packaging

Natural radioactivity in Fifty points distributed in a selected area at seila region, southeastern desert of Egypt was measured. The stream sediments natural radioactivity content in this area using a portable RS-230 Gamma-Ray Spectrometer (1,024 channels). The specific activities (Bq kg-1) of natural radionuclides 238U, 232Th and 40K are determined. The radiological hazard parameters, Radium equivalent activities (Raeq), external and internal hazard indices (Hext, Hin), external and internal level indices (Iγ, Iα), activity utilization index (I), absorbed dose rates in the air (DR), the annual effective dose (AED) and excess lifetime cancer risk (ELCR) are calculated and compared with the UNSCAER and other worldwide ranges. The average values of the 238U, 232Th and 40K activity concentrations in the studied area are 38.51±10.83 33.35±8.82 and 659.18±110.87 Bq kg-1 respectively. These values are higher than the worldwide average of 238U and 40K, 33 and 412 Bq kg-1, and lower than for 232Th of 45 Bq kg-1 according to UNSCEAR report. The Clark value (232Th/238U) is found between 1.07 to 7.22 with a mean value of 2.69±1.32 concentration ratio is presented and discussed. 20% of Clark values are higher than the worldwide average value and the most sites (80%) lower than the worldwide average value. All radiological hazard parameters are statistically presented and discussed.

Neuronal damage is induced by a neurotoxic dose of N-methyl-D-aspartate (NMDA) into CA1 area. This study was aimed to evaluate the effect of NMDA-induced excitotoxicity in CA1 on memory deficit as well as protective effect of vitamin K with potential neuroprotective properties in male rats.\nMethods: passive avoidance learning and open field tests were used to assess the recognition memory. In both tests, the retention session was conducted 24 hours after training. NMDA (20µg/µL) was injected through cannula and vitamin K (10mg/kg) were administered (s.c.) for thirty days.\nResults: During the retention sessions, NMDA decreased step-through latency (STL) and increased time in dark compartment (TDC). Also, NMDA reduced locomotor activity and rearing numbers in open field test. Vitamin K increased STL and decreased TDC in NMDA treated rats. Lower locomotor activity and rearing numbers were observed in NMDA administered rats receiving vitamin K. \nConclusion: We found that NMDA administration into CA1 region induced memory deficit in passive avoidance and open field tests. Also, the results indicated that vitamin K has a protective effect on NMDA-induced excitotoxic neuronal damage and may improve memory impairments.

Sphaeranthus indicus flowers have traditional uses in inflammation and cancer. However, literature lacks scientific investigation on S. indicus in these diseases. Therefore, current study aimed to determine the anti-cancer potentials of S. indicus extract (Si.Cr) and its fractions. S. indicus flowers were extracted with methanol followed by fractionation using n-hexane, chloroform, ethyl acetate and n-butanol. The phytochemical analysis of Si.Cr and its fractions was performed using chemical tests. Total phenolic and flavonoid contents were estimated by Folin-Ciocalteau and aluminium chloride methods, respectively. The cytotoxic effect was measured using brine shrimp lethality (BSL) and anti-cancer potential against breast cancer (MCF-7) cells was evaluated using MTT assay. Apoptosis and ROS generation in MCF-7 cells was determined using fluorescent microscopy. Phytochemical analysis indicated the presence of alkaloids, carbohydrates, phenols, flavonoids, saponins, phytosterols, glycosides, tannins, proteins, oils and resins in Si.Cr. These constituents were unevenly distributed in fractions. Si.Cr and fractions contained 28.05±0.073–122.67±1.29 mg GAE/g of sample of phenolic contents and 11.21±0.065–39.73±0.03 mg RE/g of sample of flavonoid contents. The BSL assay presented strong activity (LD50=100.13 µg/mL) for Si.Cr. In MTT assay, Si.Cr and its fractions were more active against breast cancer cells than normal cells (maximum tested dose 500 μg/mL). Furthermore, microscopic analysis presented that Si.Cr and fractions have considerable potential for apoptosis and ROS production. These findings suggest that S. indicus may has potential for safer and effective alternative to conventional chemotherapy.

In this paper, the fabrication of bottom gate top contact ZnO thin-film transistor (TFT) at room temperature using RF-sputtering and PLD method respectively have been reported. The AL2O3 dielectric layer was used and was deposited using the RF-sputtering method. The structural, surface morphology and electrical properties were evaluated, studied and compared systematically. The ZnO TFT fabricated by RF-sputtering method exhibits a superior performance as compared to ZnO TFT fabricated by the PLD method. This superiority is owed to the higher crystallinity, large grain size and less surface roughness of ZnO thin film obtained by RF sputtering method.

S-metric space is a new concept in the literature. Now a days generalization\nof S-metric spaces and fixed point theory in these spaces attracts much attention of research. The concept of S-Menger spaces was recently introduced in the literature as a generalization of S-metric spaces as well as Menger spaces. There are very few works in\nS-metric spaces which includes Banach and Kannan type contractions. In this paper we give a fixed point result in S-Menger spaces which includes Banach type contractions and Kannan type contractions. Some Corollaries have been deduced from our result and an\nexample is provided to validate our result.

The variation of subthreshold swing(SS) according to the projected range (Rp) and standard projected deviation (σ_p) was analyzed when the symmetrical junctionless double gate (JLDG) MOSFET was doped with Gaussian doping profile in this paper. For this purpose, the analytical SS model was presented. We compared with the TCAD results in order to prove the validity of this model, and the SS of this model agreed with that of TCAD. The effective conduction path and mean doping concentration affecting the SS were analyzed according to the Rp and σ_p. As a result, the SS increased as the Rp and σ_p increased simultaneously. The smaller the Rp and the larger the σ_p, the lower the SS. When Rp = 1.5 nm, it showed the SS swing below 100mV/dec without being affected by the change of σ_p or silicon thickness. When σp = 3nm, it was also 100mV/dec or less regardless of the change of Rp and silicon thickness.

Periodontal inflammation is known to contribute to various systemic diseases. The branch of Periodontal Medicine has gained a lot of importance recently. Interest in the oral systemic link has been growing and a correlation between periodontal disease and diabetes mellitus, stoke, adverse pregnancy outcomes, respiratory infections etc. has been validated through studies. Presently COVID-19 has had a massive negative impact on the population worldwide and its severity has been linked to systemic inflammation. Cytokines play an important role in aggravating COVID-19 symptoms which in turn causes an increase in the mortality rates in these patients. As periodontal disease also leads to systemic inflammation and an increased levels of inflammatory cytokines, COVID-19 severity may also be linked to the presence of periodontitis. Periodontitis is preventable and treatable and the periodontist may play a significant role in controlling the severity in certain COVID-19 patients. This review discusses how the two diseases may be interrelated and how periodontal disease may be an aggravating factor for COVID-19.